Asthma or Other Breathing Disorders and Cannabis and Scientific Journal Supporting Info

Nature, a peer-reviewed scientific journal, stated in a Nov. 2, 2000 article titled “Bidirectional Control of Airway Responsiveness by Endogenous Cannabinoids” by Calignano et al.:

“Smoking marijuana or administration of its main active constituent, THC, may exert potent dilating effects on human airways. But the physiological significance of this observation and its potential therapeutic value are obscured by the fact that some asthmatic patients respond to these compounds with a paradoxical bronchospasm [constriction of the air passages of the lung] .

The mechanisms underlying these contrasting responses remain unresolved. Here we show that endogenous cannabinoid anandamide exerts dual effects on bronchial responsiveness in rodents: it strongly inhibits bronchospasm and cough evoked by the chemical irritant, capsaicin, but causes bronchospasm when the constricting tone exerted by the vagus nerve is removed.”

Nov. 2, 2000 – Click here for Source Info

Daniele Piomelli, PhD, Professor of Pharmacology at the University of California at Irvine, told Reuters in 2000:
“We think that by targeting cannabinoid receptors in the upper airways we can control coughs in a number of conditions…That’s important because most treatments currently available basically act on the brain cough center, a small region of the brain that is the target for codeine and similar drugs .”

2000 – Click here for Source Info

Donald P. Tashkin, MD, Professor of Pulmonary Care at the University of California, Los Angeles, stated in a 1975 article titled “Effects of Smoked Marijuana in Experimentally Induced Asthma” in the American Journal of Respiratory and Critical Care Medicine:
“After exercise induced bronchospasm,[exercise-induced asthma] placebo marijuana and saline were followed by gradual recovery during 30 to 60 min, whereas 2.0 per cent marijuana…caused an immediate reversal of exercise-induced asthma and hyperinflation.”

1975 – Click here for Source Info


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